Analysis of Historical Control Litter Parameters of Reproduction Toxicity Studies in Sprague-Dawley Derived Rats
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Reproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats
The present study was conducted to obtain information on the effects of amitraz on reproductive and developmental parameters in rats. The test chemical was administered via the drinking water containing 0, 40, 120, and 360 ppm to male rats from 2 weeks before mating to the end of 14-day mating period and to females from 2 weeks before mating, throughout mating, gestation and up to lactational d...
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Methacrylonitrile (MeAN) is used in the preparation of plastics, elastomers, homoand copolymers and coatings (Windholz, 1983; Sax and Lewis, 1987) and as a chemical intermediate in the preparation of numerous organic chemicals (Windholz, 1983). MeAN is also used as a replacement for acrylonitrile in the manufacture of carbonated beverage containers (Cosidine, 1974) and is identified as a compon...
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Among organophosphorus pesticides, malathion is considered a relatively safe compound. Malathion, however, functions by inhibiting cholinesterase (ChE) enzymes of the nervous system in both vertebrate and invertebrate organisms. The inactivation of ChE by malathion is therefore a useful indicator of exposure. Because of the increased application of these pesticides, their entry into various env...
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Purified vomitoxin was incorporated into the diet at a level of 20 ppm and fed to male Sprague-Dawley rats ad lib. for 90 days. Few clinical signs of toxicity were observed. Rats in the vomitoxin treatment group were less efficient in converting feed into body mass, but there was no feed refusal. Terminal body weight was reduced in the vomitoxin treatment group. There were no statistically sign...
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A 90-day oral toxicity study of γ-oryzanol, a rice-derived triterpenoid ferulate, was performed by oral gavage administration to male and female Sprague-Dawley rats at doses of 0, 1000, and 2000 mg/kg body weight/day. All rats administered γ-oryzanol survived throughout the study period. Both male and female rats showed no toxicologically significant changes of the general signs, examination fi...
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ژورنال
عنوان ژورنال: Experimental Animals
سال: 1989
ISSN: 0007-5124,1881-7122
DOI: 10.1538/expanim1978.38.2_127